We use computational tools and biochemical assays to discover small molecule inhibitors for the E. coli chaperone SurA that could be useful in the development of new antibiotics
We study the influence of overexpressing stress-responsive transcription factors on the formation and composition of E. coli biofilms
We aim to detect sub-inhibitory concentrations of antibiotics by monitoring stress-responsive transcriptional pathways at the mRNA level.
Our lab recently published work describing the impact of the sugar L-rhamnose on the E. coli transcriptome and biofilm formation. Read all about it over at Microorganisms!
Jenna Frizzell (OC ’23) and Ryan Taylor (OC ’23) just published their most recent work “Constitutive Activation of RpoH and the Addition of L-arabinose Influence Antibiotic Sensitivity of PHL628 E. coli” that was recently published Read more…
Congrats to Luke, Maddie, Kyogo, Emma, Josh and Sarel for their hard work on a just-accepted manuscript: “Temperature-dependent influence of FliA overexpression on PHL628 E. coli biofilm growth and composition” in Frontiers in Cellular and Read more…