Areas of Research

Currently, the Ryno Lab has three primary areas of research.

Influence of Sugars on Biofilm and the Transcriptome

We use computational tools and biochemical assays to discover small molecule inhibitors for the E. coli chaperone SurA that could be useful in the development of new antibiotics

Activation of Stress-Responsive Transcription Factors

We study the influence of overexpressing stress-responsive transcription factors on the formation and composition of E. coli biofilms

Detection of Sub-Inhibitory Concentrations of Antibiotics

We aim to detect sub-inhibitory concentrations of antibiotics by monitoring stress-responsive transcriptional pathways at the mRNA level.


What's happening in the Ryno lab...

Congrats Erica!

Erica Zheng (OC ’17), chemical biology Ph.D. candidate and member of the Collins’ lab at Harvard University, just published a great paper “Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics” in Cell Read more…

Lisa M. Ryno, Ph.D.

Associate Professor of Chemistry and Biochemistry

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