We use computational tools and biochemical assays to discover small molecule inhibitors for the E. coli chaperone SurA that could be useful in the development of new antibiotics
We study the influence of overexpressing stress-responsive transcription factors on the formation and composition of E. coli biofilms
We aim to detect sub-inhibitory concentrations of antibiotics by monitoring stress-responsive transcriptional pathways at the mRNA level.
Congrats to Luke, Maddie, Kyogo, Emma, Josh and Sarel for their hard work on a just-accepted manuscript: “Temperature-dependent influence of FliA overexpression on PHL628 E. coli biofilm growth and composition” in Frontiers in Cellular and Read more…
Erica Zheng (OC ’17), chemical biology Ph.D. candidate and member of the Collins’ lab at Harvard University, just published a great paper “Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics” in Cell Read more…
A big congratulations go out to Luke Buck OC ’21 for winning the Oberlin College Robert Rich Award! His award winning proposal will continue to fund our exploration of what signaling pathways influence biofilm formation Read more…
Oberlin College
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